產(chǎn)品介紹:
諾爾絲菌素是由諾爾斯鏈霉菌中產(chǎn)生的廣譜性抗生素,對(duì)原核和真核細(xì)胞都有抑制作用,包括高等真核生物細(xì)胞。它也被認(rèn)為是對(duì)某些DNA和RNA病毒有一定抑制效果。
通常,它作為含有抗性基因細(xì)胞篩選劑已被應(yīng)用于分子遺傳學(xué),通過(guò)sat1 基因的產(chǎn)物諾爾絲菌素氨乙酰轉(zhuǎn)移酶對(duì)ß-賴(lài)氨酸的ß-氨基進(jìn)行單乙酰化作用導(dǎo)致NTC的失活從中選出重組菌株。
像氨基糖苷類(lèi)抗生素一樣,諾爾絲菌素誘導(dǎo)錯(cuò)誤編碼;因此干擾蛋白質(zhì)的合成;然而,它卻是一個(gè)鏈絲菌素類(lèi)抗生素。
諾爾絲菌素硫酸鹽(鏈絲菌素硫酸鹽)
Nourseothricin Sulfate
Streptothricin Sulfate, NTC, clonNAT
MOLECULAR BIOLOGY GRADE
C31H58N12O10 · C19H34N8O8 · H2SO4
MW: 1359.47 g/mol
Norseothricin contains both Streptothricin D (C31H58N12O10) and Streptothricin F (C19H34N8O8) components.
Mode of action and Anti-microbial spectrum Nourseothricin Sulfate is a Streptothricin-class antibiotic that has an extremely broad spectrum of activity against viruses, bacteria, eukaryotic unicellular and complex organisms. Recombinant strains are selected for by the inactivation of NTC by monoacetylation of ?-amino group of the ?-lysine by the product of the sat1 gene, Nouresothricin N-acetyltransferase.
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