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We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX111:

1. Donald F. Sellitti, Yueh-Chu L. Tseng and Keith R. Latham, (1983), Nuclear Thyroid Hormone Receptors in C3H/HeN Mouse Mammary Glands and Spontaneous Tumors, Cancer Research 43 (3): 1030-1038.

References for NEX111H:

1. Sotelo-Rivera, I., Jaimes-Hoy, L., Cote-Vélez, A., Espinoza-Ayala, C., Charli, J.-L. and Joseph-Bravo, P. (2014), An Acute Injection of Corticosterone Increases Thyrotrophin-Releasing Hormone Expression in the Paraventricular Nucleus of the Hypothalamus but Interferes with the Rapid Hypothalamus Pituitary Thyroid Axis Response to Cold in Male Rats. J Neuroendocrinol, 26: 861–869.

References for NEX111X:

1. DuRant, S.E., Carter, A.W., Denver, R.J., Hepp, G.R., Hopkins, W.A., (2014), Are thyroid hormones mediators of incubation temperature-induced phenotypes in birds? Biology Letters, 10: .