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SR-95531 acts as an antagonist at GABA_A receptors. These receptors are ligand-gated ion channels and are the target for many psychoactive drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET946:

1. Yanlin Lei, Irene Yaroslavsky, Shanaz M. Tejani-Butt, Strain differences in the distribution of N-methyl-d-aspartate and gamma (γ)–aminobutyric acid-A receptors in rat brain, Life Sciences, Volume 85, Issues 23–26, 2009, Pages 794-799.
2. Jon E. Hawkinson, Manuel Acosta-Burruel, Catherine L. Kimbrough, Dayan B. Goodnough, Paul L. Wood, Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site, European Journal of Pharmacology, Volume 304, Issues 1–3, 1996, Pages 141-146.