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AH5183 (vesamicol, (2-hydroxyethyl)-1-piperazine-ethanesulfonic acid, (4-phenylpiperidino) cyclohexanol) is a cholinergic vesicular uptake blocker. Vesicular acetylcholine transporters (VAChT) are neurotransmitter transporters involved in acetylcholine secretion. Vesamicol inhibits the transport of acetylcholine into synaptic vesicles in nerve terminals, and play a role in drug response and vulnerability to drug addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET964:

1. Ojeda A.M., Bravo D.T., Hart T.L., Parsons S.M. (2003) Equilibrium Binding and Transport Studies. In: Yan Q. (eds) Membrane Transporters. Methods in Molecular Biology, vol 227. Humana Press.