“白介素2受體γ鏈抗體，Anti-IL-2R gamma/CD132抗體”應(yīng)用于IHC、WB、 IF、IP、ELISA，質(zhì)量保證，無效免費退換，另外本公司生產(chǎn)經(jīng)營各種標(biāo)記二抗、免疫印跡常用試劑、免疫組化常用試劑，咨詢！

產(chǎn)品介紹：

【產(chǎn)品名稱】：白介素2受體γ鏈抗體，Anti-IL-2R gamma/CD132抗體

【產(chǎn)品類型】：一抗

【產(chǎn)品編號】：BYk-2545R                     

【相關(guān)標(biāo)記】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647

【性 狀】： Lyophilized or Liquid

【濃 度】： 1mg/1ml

【亞 型】： IgG

【規(guī) 格】：0.1ml/100ug，0.2ml/200ug

【抗體來源】： Rabbit OR MOUSE

【克隆類型】： polyclonal or monoclonal

【產(chǎn)品用途】：科研實驗，用于免疫組化實驗，WB實驗、IF、IP、ELISA實驗，相應(yīng)的標(biāo)記抗體有HRP標(biāo)記抗體，F(xiàn)ITC標(biāo)記，BIO等。

【貯 存】： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

【詳細介紹】：Interleukin 2 （IL2） receptor gamma chain （IL5212R gamma） is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 （IL2R alpha）, CD122 （IL2R beta）, CD124 （IL4R alpha）, CD127 （IL7R）, and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins.
In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 （Janus Kinase 3）, JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 （Signal Transducer and Activator of Transcription 3）, STAT5, and STAT6.
The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency （X SCID）, a disease that is characterized by the absence of T cells and NK cells.
白介素2受體γ鏈抗體，Anti-IL-2R gamma/CD132抗體【相關(guān)產(chǎn)品】：
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Anti-IL-10  白介素10抗體
Anti-IL-11  白介素11抗體
Anti-IL-10Ra/IL10RA/CD210  白細胞介素-10受體a抗體
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Anti-IL-12  白介素12抗體（白細胞介素-12）
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Anti-IL-12Rβ1/CD212  白細胞介素-12受體β1抗體
Anti-IL-12Rβ2  白細胞介素-12受體β2抗體
Anti-IL-13  白介素13抗體
Anti-IL-14/Taxilin alpha  白介素14抗體（白細胞介素-14）
Anti-IL-15Rα  白介素15受體α抗體
Anti-IL-15  白介素15抗體（白細胞介素-15）