曙紅Y(水溶) 號(hào)：17372-87-1  
英文名稱：Eosin Y sodium salt water soluble；Eosin Y water soluble；Bromofluorescein；Bronze bromo ES；   
Bromofluoresceic acid；Bromoeosine；Acid red 87；2′,4′,5′,7′-Tetrabromofluorescein disodium salt；Eosin(water soluble)；Eosin   
其他名稱：伊紅Y(水溶)；水溶伊紅；朝紅；四溴熒光素二鈉；曙紅鈉鹽；四溴熒光黃；曙紅變性次甲藍(lán)；黃光曙紅；曙紅微黃；酸性紅87；2',4',5',7'-四溴-3',6'-二羥基螺[異苯丙呋喃-1(3H),9'(9H)-占噸]-3-酮二鈉鹽    
號(hào)：17372-87-1   
C20H6Br4Na2O5=691.85   
級(jí)別：BS    
含量：≥85.0%   
干燥失重：≤9.0%   
鹵化物：≤2.0%   
靈敏度實(shí)驗(yàn)：合格   
乙醇溶解試驗(yàn)：合格   
Z大吸收波長(zhǎng)：510～518nm   
性狀(以下信息僅供參考)：紅色具藍(lán)光結(jié)晶或棕色粉末，易溶于水，稍溶于醇，不溶于醚，濃的水溶液為深棕紅色，其稀溶液（1：500）為黃紅色顯綠色熒光，醇溶液有很強(qiáng)的綠色熒光。用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)用作生物染色劑，肽和蛋白質(zhì)、原生質(zhì)、堿性磷酸酶等染色。光度測(cè)定銀(次微克量)。賴特血球著色劑(Wright stain)組分，用于檢別血球。也用作吸附指示劑，滴定溴、碘、氟等離子。用作顯色劑，用于熒光光度法測(cè)定Ag＋、Pb2＋、Mn2＋、Zn2＋等   
保存：RT 
曙紅Y(水溶) 號(hào)：17372-87-1儲(chǔ)存條件：
避光、干燥陰涼處封閉貯存,嚴(yán)禁與有毒、有害物品混放、混運(yùn)。本品為非危險(xiǎn) 產(chǎn)品可按一般化學(xué)品運(yùn)輸,輕搬動(dòng)輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運(yùn)輸條件比較苛刻。
運(yùn)輸：汽車運(yùn)輸、EMS郵政快遞，申通快遞等， 款到上海3天內(nèi)發(fā)貨；
售后：如您對(duì)我們的產(chǎn)品服務(wù)及技術(shù)指標(biāo)有特殊要求，請(qǐng)及時(shí)通知我方。
存儲(chǔ)：應(yīng)貯存在干燥清潔避光的環(huán)境中，嚴(yán)禁與有毒物質(zhì)混放，以免污染（保質(zhì)期為兩年）。
曙紅Y(水溶) 號(hào)：17372-87-1主要優(yōu)級(jí)純、分級(jí)純和化學(xué)純3種：
（1）優(yōu)級(jí)純（GR：Guaranteed reagent），又稱一級(jí)品或保證試劑，99.8%，這種試劑純度Z高，雜質(zhì)含量Z低，適合于重要精密的分析工作和科學(xué)研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱二級(jí)試劑，純度很高，99.7%，略次于優(yōu)級(jí)純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學(xué)純（CP），又稱三級(jí)試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學(xué)校一般分析工作。使用藍(lán)色（深藍(lán)色）標(biāo)簽。
（4）實(shí)驗(yàn)試劑（LR：Laboratory reagent），又稱四級(jí)試劑。
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產(chǎn)品介紹 The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle.
Function : Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Subunit : Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1.
Subcellular Location : Nuclear.
Tissue Specificity : Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
Post-translational modifications : hosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.
Similarity : Contains 1 C3HC-type zinc finger.
曙紅Y(水溶) 號(hào)：17372-87-1Database links : UniProtKB/Swiss-Prot: Q86WB0.1
英文名稱  Anti-Nucleolin/C23
中文名稱  核仁蛋白C23抗體
別    名  C23; NCL; Nucl; NUCL_HUMAN; Nucleolin; Protein C23.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來(lái)源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat, Dog, Pig, Cow, Horse
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 染色質(zhì)和核信號(hào) 表觀遺傳學(xué) 
蛋白分子量  predicted molecular weight: 76kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Nucleolin
亞    型  IgG
純化方法  affinity purified by Protein A
儲(chǔ) 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-F=1:100-500  IF=1:50-200
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.