橙黃G6 號：1936-15-8  
英文名稱：Orange G6；Orange G sodium salt；Acid orange 10；Wool orange 2G；Acid orange G；Fast light orange G ；C.I. 16230    
其他名稱：金橙G；桔黃G；橙黃GG；酸性耐光桔黃；酸性橙10；橙黃G鈉；1-苯基偶氮-2-萘酚-6,8-二磺酸鈉；耐光橙G；橙黃G；7-羥基-8-(苯基偶氮基)-1,3-萘二磺酸二鈉鹽；酸性橙GG；橙G；酸性耐光桔黃   
號：1936-15-8   
C16H10N2Na2O7S2=452.37    
級別：BS   
生物染色試驗：合格   
性狀(以下信息僅供參考)：黃紅色粉末或結晶性小片。溶于水和乙醇，不溶于乙迷和方。水溶液為橙黃色，乙醇溶液為橙色，鹽酸對水溶液無變化，遇氫氧化鈉呈黃紅色，遇化鈣生成結晶性鈣鹽。Z大吸收波長475nm。pH變色范圍11.5(黃)～14.0(橙紅)   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)酸堿指示劑、生物染色劑。用于Mallory's 結締組織染色等。SDS-毛細管電泳中蛋白分離標準，也是核酸電泳的跟蹤染料。比溴酚藍遷移快，能檢測到更小的DN片段。   
保存：RT 橙黃G6 號：1936-15-8 儲存條件：
避光、干燥陰涼處封閉貯存,嚴禁與有毒、有害物品混放、混運。本品為非危險 產(chǎn)品可按一般化學品運輸,輕搬動輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運輸條件比較苛刻。
運輸：汽車運輸、EMS郵政快遞，申通快遞等， 款到上海3天內(nèi)發(fā)貨； 
售后：如您對我們的產(chǎn)品服務及技術指標有特殊要求，請及時通知我方。 
存儲：應貯存在干燥清潔避光的環(huán)境中，嚴禁與有毒物質(zhì)混放，以免污染（保質(zhì)期為兩年）。 
橙黃G6 號：1936-15-8 主要優(yōu)級純、分級純和化學純3種：
（1）優(yōu)級純（GR：Guaranteed reagent），又稱一級品或保證試劑，99.8%，這種試劑純度Z高，雜質(zhì)含量Z低，適合于重要精密的分析工作和科學研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱二級試劑，純度很高，99.7%，略次于優(yōu)級純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學純（CP），又稱三級試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學校一般分析工作。使用藍色（深藍色）標簽。
（4）實驗試劑（LR：Laboratory reagent），又稱四級試劑。
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產(chǎn)品類型  一抗   
研究領域  細胞生物 神經(jīng)生物學 信號轉導 
蛋白分子量  predicted molecular weight: 45kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NR2E3 (1-100aa)
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Photoreceptor-specific nuclear receptor, also known as NR2E3 or PNR, belongs to a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E3 has a role in regulating the signaling pathway elemental to the photoreceptor cell function and in regulating pathways involved in embryonic development. NR2E3 is an eye specific nuclear protein found in the outer nuclear layer of the adult retina (where the nuclei of cone and rod photoreceptors are located). Defects in this gene encoding for the protein, which localizes to chromosome 15q22.32, cause enhanced S cone syndrome.
Function : Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M-and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Subunit : Interacts with PIAS3; the interaction sumoylates NR2E3 and promotes repression of cone-specific gene transcription and activation of rod-specific genes (By similarity). Component of a complex that includes NR2E3, PIAS3, NRL, CRX and/or NR1D1. Binds NR1D1. Binds direcly in the complex with CRX, PIAS3 and NR1D1 (By similarity). Interacts (via the DNA-binding domain) with CRX (via its DNA binding domain); the interaction represses S- and M-cone opsin expression.
Subcellular Location : Nucleus.
Tissue Specificity : Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.
Post-translational modifications : Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site.
DISEASE : Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration.
Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant.
Similarity : Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links : UniProtKB/Swiss-Prot: Q9Y5X4.1
英文名稱  Anti-Nicalin/NCLN
中文名稱  γ-分泌酶組件蛋白NCLN抗體
別    名  NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like