公司提供的衛(wèi)矛醇號：608-66-2*，貨源充足。嚴(yán)格的生產(chǎn)質(zhì)量控制體系，包括：優(yōu)級純，分析純，化學(xué)純，試劑級，基準(zhǔn)試劑，實驗純，教學(xué)試劑，高純試劑，色譜純，光譜純，電子純。各種包裝規(guī)格，并可提供包裝定制，咨詢訂購。
衛(wèi)矛醇號：608-66-2   
英文名稱：Dulcitol；Galactitol；Euonymit；Melampyrite；Melampyrin     
其他名稱：甜醇；衛(wèi)茅醇；半乳糖醇；己六醇   
號：608-66-2    
C6H14O6=182.17   
級別：BR   
含量：≥98.0%    
熔點：185～189℃   
重金屬：≤10ppm   
性狀(以下信息僅供參考)：白色結(jié)晶性粉末或單斜柱狀結(jié)晶，味微甜。農(nóng)作物提取，1g溶于2ml沸水、30ml冷水，微溶于乙醇。相對密度(d20)1.47。沸點 275～280℃(0.13kPa)。    
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)微生物學(xué)和生物化學(xué)研究   
保存：RT 客戶根據(jù)衛(wèi)矛醇號：608-66-2性質(zhì)、化學(xué)式、分子式、結(jié)構(gòu)式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產(chǎn)品化學(xué)性質(zhì)穩(wěn)定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風(fēng)良好的地方，遠離不相容的物質(zhì)。保持容器密閉。
試劑品牌：TCI、sigma、Alfa、Avocado、Aldrich、ACROS、Fluka、ICN（MP）等
包裝：1kg、100g、10g、250g、25g、500g、50g、5g等包裝
級別：GR級別、AR級別、CP級別、L.P.級別等

購買須知：
【價格方面】
每個時期原料的價格都會波動，產(chǎn)品的價格會有所升降，以上報價僅為參考報價！咨詢選購！

【付款方式】
現(xiàn)金，支付寶，銀行轉(zhuǎn)帳，匯款，支票，本票；
請將款項匯至我司公司賬戶（開票的）或者老板的私人賬戶上面，接受支付寶付款；
我司收到款項后會根據(jù)客戶的相關(guān)要求盡快安排發(fā)貨！

【發(fā)貨時間】
物流基本上在下午2點之前提交確認(rèn)的訂單，都將盡力安排當(dāng)天發(fā)貨；
如果訂單產(chǎn)品需要拆分及其他特殊情況的要求，則可能會有一定的延時。

【配送方式】
確定的訂單后，小貨我司將通過順豐、韻達等快遞送達；
大量貨物會更具情況以德邦、遠成，普華，中鐵等物流的運輸方式發(fā)貨。

【其他服務(wù)】
如您對產(chǎn)品特性及技術(shù)指標(biāo)有特殊要求，我公司可以提供質(zhì)檢單和相關(guān)產(chǎn)品的資料和文件；
如果對產(chǎn)品的包裝或者分裝的有要求的話，也請及時通知我方，我方好根據(jù)要求盡量滿足您的所需求。

【服務(wù)宗旨】
竭誠提供優(yōu)質(zhì)產(chǎn)品，售后服務(wù)客戶滿意度100％
服務(wù)承諾：工作時間內(nèi)提供免費的技術(shù)咨詢和指導(dǎo) 。我公司的技術(shù)人員都經(jīng)過專業(yè)培訓(xùn)的，將為您提供滿意的產(chǎn)品和真誠的服務(wù)。
Function : Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Subunit : Monomer; in the absence of TGF-beta. Homooligomer; in the presence of TGF-beta. Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex. Interacts with TGFBR1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with AIP1, TGFB1I1, TTRAP, FOXL2, PML, PRDM16, HGS and WWP1. Interacts (via MH2 domain) with CITED2 (via C-terminus) (By similarity). Interacts with NEDD4L; the interaction requires TGF-beta stimulation (By similarity). Interacts (via the MH2 domain) 衛(wèi)矛醇號：608-66-2with ZFYVE9. Interacts with HDAC1, VDR, TGIF and TGIF2, RUNX3, CREBBP, SKOR1, SKOR2, SNON, ATF2, SMURF2 and TGFB1I1. Interacts with DACH1; the interaction inhibits the TGF-beta signaling. Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Found in a complex with SMAD3, RAN and XPO4. Interacts in the complex directly with XPO4. Interacts (via the MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus. Interacts with RBPMS. Interacts (via MH2 domain) with MECOM. Interacts with WWTR1 (via its coiled-coil domain). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3. This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity. Interacts with SKI; the interaction represses SMAD3 transcriptional activity. Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta. Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling. Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling. Interacts with MEN1. Interacts with IL1F7. Interaction with CSNK1G2. Interacts with PDPK1 (via PH domain).
Subcellular Location : Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta.
Post-translational modifications : Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF AND TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1.
Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta.
Ubiquitinated.
DISEASE : Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500].
Defects in SMAD3 are the cause of Loeys-Dietz syndrome type 1C (LDS1C) [MIM:613795]. LDS1C is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by the triad of arterial tortuosity and aneurysms, hyperorism, and bifid uvula or cleft palate. Patients with LDS1C also manifest early-onset osteoarthritis. They lack craniosynostosis and mental retardation.
Similarity : Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.
Database links :
Entrez Gene: 4088 Human
Entrez Gene: 17127 Mouse
Entrez Gene: 25631 Rat
Omim: 603109 Human
SwissProt: P84022 Human
SwissProt: Q8BUN5 Mouse
SwissProt: P84025 Rat
Unigene: 727986 Human
Unigene: 7320 Mouse
Unigene: 10636 Rat
英文名稱  Anti-Syntrophin-1
中文名稱  神經(jīng)肌肉接頭蛋白SNTA1抗體
別    名  Syntrophin alpha 1; SNTA1_HUMAN; Alpha-1-syntrophin; 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; Syntrophin-1.
濃    度  1mg/1ml
規(guī) 格  0.2ml/100μg  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 神經(jīng)生物學(xué) 結(jié)合蛋白 
蛋白分子量  predicted molecular weight: 56kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Syntrophin-1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-