公司提供的海藻酸 號：9005-32-7*，貨源充足。嚴(yán)格的生產(chǎn)質(zhì)量控制體系，包括：優(yōu)級純，分析純，化學(xué)純，試劑級，基準(zhǔn)試劑，實(shí)驗(yàn)純，教學(xué)試劑，高純試劑，色譜純，光譜純，電子純。各種包裝規(guī)格，并可提供包裝定制，咨詢訂購。
海藻酸 號：9005-32-7  
英文名稱：Alginic acid from brown algae；Mixed polymer of mannuronic and guluronic acid   
其他名稱：藻朊酸；藻酸；褐藻酸；藻蛋白酸；澡朊酸   
號：9005-32-7    
分子式：(C6H8O6) n   
級別：BR   
含量(羧基基團(tuán)) (以干基計(jì))：19 - 25 % (滴定分析法)   
紅外光譜鑒定Infrared spectrometry：和對照品匹配   
干燥損失：<15 % (2 g, 105°C, 4 小時(shí))    
淀粉：不顯藍(lán)色   
重金屬：≤0.004％    
砷鹽：≤0.0003％    
性狀(以下信息僅供參考)：白色到淺黃棕色、無臭、無味的粉末。由海藻制得的一種膠體物質(zhì)，系β-無水右旋甘露糖醛酸的聚合物。溶于堿性溶液，微溶于熱水，極微溶于冷水及有機(jī)溶劑。溶于氫氧化堿金屬。3%水溶液PH值1.3～5.5，可吸收200～300倍其重量的水，溫暖條件下放置可緩慢分解，分子量變小。   
用途：本品僅供科研，不得用于其它用途。   
保存：RT客戶根據(jù)海藻酸 號：9005-32-7性質(zhì)、化學(xué)式、分子式、結(jié)構(gòu)式、比重、密度、號、沸點(diǎn)、熔點(diǎn)、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項(xiàng)、英文名、別稱、純度、級別等情況，本產(chǎn)品化學(xué)性質(zhì)穩(wěn)定，運(yùn)輸條件不苛刻，一般儲存在陰涼，干燥，通風(fēng)良好的地方，遠(yuǎn)離不相容的物質(zhì)。保持容器密閉。
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包裝：1kg、100g、10g、250g、25g、500g、50g、5g等包裝
級別：GR級別、AR級別、CP級別、L.P.級別等

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 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
Function : Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (海藻酸 號：9005-32-7TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes (By similarity).
Subunit : The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN.
Subcellular Location : Transmembrane protein: Cell membrane; Single-pass type I membrane protein (By similarity).
Surface protein: Cell membrane; Peripheral membrane protein (By similarity). Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM (By similarity).
HERV-W_7q21.2 provirus ancestral Env polyprotein: Virion (By similarity).
Tissue Specificity : Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
Post-translational modifications : Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.
The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).
Similarity : Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
Database links : UniProtKB/Swiss-Prot: Q9UQF0.1
合胞素(Syncytin)是一類由人俘獲的逆轉(zhuǎn)錄囊膜蛋白,與胎盤的形態(tài)發(fā)生中細(xì)胞滋養(yǎng)層到合胞滋養(yǎng)層的分化過程相關(guān)。Syncytin與人免疫缺陷I型(-1)囊膜蛋白(Env)在結(jié)構(gòu)上具有相似的特點(diǎn),二者可能具有相似的膜融合機(jī)制。
英文名稱  Anti-SIRT1/sirtuin 1
中文名稱  沉默調(diào)節(jié)蛋白1抗體
別    名  75SirT1; BA57G10.4; hSIR2; hSIRT1; NAD dependent deacetylase SIRT1; NAD dependent deacetylase sirtuin 1; NAD dependent deacetylase sirtuin 2; Silent mating type information regulation 2; OTTHUMP00000198111; OTTHUMP00000198112; SIR2 like 1; SIR2 like protein 1; SIR2-like protein 1; Regulatory protein SIR2 homolog 1; SIR1_HUMAN; SIR2ALPHA; SIR2alpha protein; SIR2L1; SIR2L2; SIRT 1; SIRT-1; Sirt1; SIRT1 Sir2 like proteins (siruitins) type 1; SIRT1: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); SirtT1 75 kDa fragment; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae);Sirtuin 1; sirtuin; Sirtuin type 1; Sirtuin type 2.
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Dog, Pig, Horse, Rabbit
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 微生物學(xué) 信號轉(zhuǎn)導(dǎo) 新陳代謝 表觀遺傳學(xué) 
蛋白分子量  predicted molecular weight: 58/81kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human SIRT1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Function : SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly.
Subunit : Found in a complex with PCAF and MYOD1 (By similarity). Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts with HES1, HEY2 and PML. Interacts with RPS19BP1/AROS. Interacts with KIAA1967/DBC1 (via N-terminus); the interaction disrupts the interaction between SIRT1 and p53/TP53. Interacts with SETD7; the interaction induces the dissociation of SIRT1 from p53/TP53 and increases p53/TP53 activity. Interacts with MYCN, NR1I2, CREBZF, TSC2, TLE1, FOS, JUN, NR0B2, PPARG, NCOR, IRS1, IRS2 and NMNAT1. Interacts with HNF1A; the interaction occurs under nutrient restriction. Interacts with SUZ12; the interaction mediates the association with the PRC4 histone methylation complex which is specific as an association with PCR2 and PCR3 complex variants is not found. Interacts with -1 tat.
Subcellular Location : Nucleus, PML body. Cytoplasm. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm.
SirtT1 75 kDa fragment: Cytoplasm. Mitochondrion.
Tissue Specificity : Widely expressed.
Post-translational modifications : Methylated on multiple lysine residues; methylation is enhanced after DNA damage and is dispensable for deacetylase activity toward p53/TP53.
Phosphorylated. Phosphorylated by STK4/MST1, resulting in inhibition of SIRT1-mediated p53/TP53 deacetylation. Phosphorylation by MAPK8/JNK1 at Ser-27, Ser-47, and Thr-530 leads to increased nuclear localization and enzymatic activity. Phosphorylation at Thr-530 by DYRK1A and DYRK3 acivates deacetylase activity and promotes cell survival. Phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) at Ser-47 inhibits deacetylation activity. Phosphorylated by CaMK2, leading to increased p53/TP53 and NF-kappa-B p65/RELA deacetylation activity (By similarity). Phosphorylation at Ser-27 implicating MAPK9 is linked to protein stability. There is some ambiguity for some phosphosites: Ser-159/Ser-162 and Thr-544/Ser-545.
Proteolytically cleaved by cathepsin B upon TNF-alpha treatment to yield catalytic inactive but stable SirtT1 75 kDa fragment (75SirT1).
S-nitrosylated by GAPDH, leading to inhibit the NAD-dependent protein deacetylase activity (By similarity).
Similarity : Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
Database links : UniProtKB/Swiss-Prot: Q96EB6.2
在Sirtuin蛋白家族中，sirtuin 1(沉默信息調(diào)節(jié)子)參與多種新陳代謝活動，包括DNA的自我保護(hù)和修復(fù)，抑制脂質(zhì)過氧化積累，抑制其他細(xì)胞凋亡相關(guān)基因的表達(dá)以及和細(xì)胞壽命相關(guān)的活動。限制攝入的熱量可以加強(qiáng)SIRT1的表達(dá)，從而延長了壽命。 SIRT蛋白成為多種生物過程的調(diào)節(jié)者也參與衰老的調(diào)控。在研究Z多的SIRT蛋白中，SIRT1與各種非組蛋白或者轉(zhuǎn)錄因子相互作用，包括p53、FOXO蛋白、p300、NFkB和MyoD，sirtuins可參與凋亡、細(xì)胞存活、轉(zhuǎn)錄和代謝等過程。以sirtuins為靶標(biāo)的藥物可能在治療衰老、癌癥、糖尿病和神經(jīng)退行性變中有用。
英文名稱  Anti-SCGN/Secretagogin
中文名稱  鈣結(jié)合樣蛋白/神經(jīng)內(nèi)分泌腫瘤標(biāo)記物抗體
別    名  Calbindin like; CALBL; DJ501N12.8; Scgn; SECRET; Secretagogin; Secretagogin EF hand calcium binding protein; SEGN; SEGN_HUMAN; Setagin.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit