公司提供的*號：57-88-5*，貨源充足。嚴格的生產(chǎn)質(zhì)量控制體系，包括：優(yōu)級純，分析純，化學(xué)純，試劑級，基準試劑，實驗純，教學(xué)試劑，高純試劑，色譜純，光譜純，電子純。各種包裝規(guī)格，并可提供包裝定制，咨詢訂購。
*號：57-88-5   
英文名稱：Cholesterol；Cholest-5-en-3beta-ol；3beta-hydroxycholest-5-ene；3beta-hydroxy-5-cholestene   
其他名稱：膽甾醇；膽甾醇烷；異辛甾烯醇；膽固烯醇；膽脂醇；膽脂素；膽脂素醇；(3β)-膽甾-5-烯-3-醇；膽甾-5-烯-3β-醇；膽甾烷醇   
號：57-88-5   
C27H46O=386.66   
級別：AR    
含量：≥95.0%   
熔點：147～150℃   
酸度：≤0.5ml   
干燥失重：≤1.0%   
性狀(以下信息僅供參考)：白色或淡黃色有珠光的片狀結(jié)晶，在空氣中緩慢氧化變黃，溶于苯、石油及油脂，微溶于乙醇(20℃，1.29g/100g)，稍多溶于熱乙醇(80℃，96％乙醇，28g/100g)，幾乎不溶于水(約0.2mg/100ml)。本品1g溶于2.8ml乙迷、4.5ml方   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)腦磷脂*絮狀試驗   
保存：RT，避光客戶根據(jù)*號：57-88-5性質(zhì)、化學(xué)式、分子式、結(jié)構(gòu)式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產(chǎn)品化學(xué)性質(zhì)穩(wěn)定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風良好的地方，遠離不相容的物質(zhì)。保持容器密閉。
試劑品牌：TCI、sigma、Alfa、Avocado、Aldrich、ACROS、Fluka、ICN（MP）等
包裝：1kg、100g、10g、250g、25g、500g、50g、5g等包裝
級別：GR級別、AR級別、CP級別、L.P.級別等

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交叉反應(yīng)  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit
產(chǎn)品類型  一抗  磷酸化抗體  
研究領(lǐng)域  腫瘤 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細胞粘附分子 細胞類型標志物 新陳代謝 
蛋白分子量  predicted molecular weight: 48kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human SYT1 around the phosphorylation site of Thr202
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Function : May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Subunit : Homotetramer (Probable). Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity).
Subcellular Location : Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.
Similarity : Belongs to the synaptotagmin family.
Contains 2 C2 domains.
Database links : UniProtKB/Swiss-Prot: P21579.1
英文名稱  Anti-SIRT6
中文名稱  沉默調(diào)節(jié)相關(guān)蛋白6抗體
別    名  2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat
產(chǎn)品類型  一抗   
研究領(lǐng)域  腫瘤 心血管 免疫學(xué) 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 細胞凋亡 新陳代謝 表觀遺傳學(xué) 
蛋白分子量  predicted molecular weight: 39kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human SIRT6
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in omeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with omeres during S-phase and for normal omere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.
Function : NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in omeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with omeres during S-phase and for normal omere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Subunit : Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.
Subcellular Location : Nucleus, nucleoplasm.
Similarity : Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.
Database links : UniProtKB/Swiss-Prot: Q8N6T7.2
SIRT6是一種酶，能夠從組蛋白的一個特定位點上移走稱之為乙酰基組的化學(xué)物質(zhì)。組蛋白對調(diào)控基因表達非常重要，而從組蛋白中移除乙?；M就會“關(guān)閉”某些基因表達。 SIRT6蛋白與NF-kappaB（NF-kB）一同，可以調(diào)節(jié)凋亡、炎癥和新陳代謝相關(guān)基因的作用。當減少SIRT6時，NF-kappaB變得過度活躍，開啟同衰老相關(guān)的基因。
英文名稱  Anti-phospho-SIRT6(Ser338)
中文名稱  磷酸化沉默調(diào)節(jié)相關(guān)蛋白6抗體
別    名  SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human