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Anti-HCN2/FITC抗體*

Form：Abcam

Catalog Number : BYK-9858R-FITC      
Quantity size :   100ug (2mg/1ml, Lyophilized or Liquid. Buffer = 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide. Reconstitute with 50ul sterile distilled water.)

Background:  Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1–4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1). HCN channels are expressed in the brain, heart, thalamus and testis (1). The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart (1). The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5).

Also known as:  BCNG-2; BCNG2; HCN 2; Brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated channel 2; HAC1; Hcn2; HCN2_HUMAN; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2.

Specificity:    -Rabbit Polyclonal IgG, affinity purified by Protein A.

-FITC conjugated

-Reacts with: Human, Mouse, Rat, Chicken, Cow, Sheep, 

-Immunogen: KLH conjugated synthetic peptide derived from human HCN2.

-Predicted molecular weight: 97kDa

Application:  Flow-Cyt=1:50-200  ICC=1:50-200  IF=1:50-200

            Excitation spectrum: 490-495nm

            Emission spectrum: 520-530nm

            Not yet tested in other applications.

            Optimal working dilutions must be determined by the end user.

Storage:     Store at -20 °C for one year. Avoid repeated freeze/thaw

            cycles. The Lyophilized or Liquid antibody is stable at room

            temperature for at least one month and for greater than a year when

            kept at -20 °C. When reconstituted in sterile pH 7.4 0.01M PBS or

            diluent of antibody the antibody is stable for at least two weeks at

            2-4 °C.

Important Note: This product as supplied is intended for research

             use only, not for use in human, therapeutic or diagnostic

             applications.