摘要阿培利司 AlpelisibAlpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential...

摘要BMN 673 TalazoparibTalazoparib, also known as BMN-673 and MDV-3800,is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-...

摘要魯卡帕尼 RucaparibRucaparib is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosens...

摘要尼拉帕尼 NiraparibNiraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor ...

摘要奧拉帕尼 OlaparibOlaparib, also known as AZD-2281 or KU-59436 , is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polym...

摘要拉羅替尼 LarotrectinibLarotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of ...

摘要恩曲替尼 EntrectinibEntrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well ...

摘要 TemsirolimusTemsirolimus is an ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR),

摘要依維莫司 EverolimusEverolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant a...

摘要曲美替尼 TrametinibTrametinib, also known as GSK1120212, is a n orally bioavailable inhibitor of mitogen-activated protein kinase kinase (...

摘要考比替尼 CobimetinibCobimetinib, also known as GDC-0973 and XL-518, RG 7420, is an orally bioavailable small-molecule inhibitor of mitogen...

摘要 貝美替尼 BinimetinibBinimetinib, also known as MEK162 (ARRY-162), is an oral, highly selective MEK inhibitor.

摘要艾伏尼布 Ivosidenib Ivosidenib, also known as AG-120 and RG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1...

摘要伊那尼布 EnasidenibEnasidenib, also known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activ...

摘要瑞戈非尼 RegorafenibRegorafenib, also known as BAY 73-4506 ; is an orally bioavailable small molecule with potential antiangiogenic and an...

摘要魯索替尼 RuxolitinibAlso known as INC424 and INCB18424 or INCB018424, is an orally bioavailable Janus-associated kinase (JAK) inhibitor wi...

摘要厄達替尼 ErdafitinibErdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor r...

摘要米哚妥林 MidostaurinMidostaurin, also known as PKC-412, PKC-412A and CGP 41251; is a synthetic indolocarbazole multikinase inhibitor with ...

摘要吉列替尼 GilteritinibGilteritinib, also known as ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity agains...

摘要 拉帕替尼 is a synthetic, orally-active quinazoline with potential antineoplastic activity.

摘要來那替尼 NeratinibNeratinib, also known as HKI-272 or PB272, is an orally available, irreversible inhibitor of the HER-2 receptor tyrosine...

摘要 奧瑞替尼 OsimertinibOsimertinib, also known as AZD-9291 and Mereletinib, is a third-generation EGFR inhibitor,

摘要達克替尼 DacomitinibDacomitinib, also known as PF-299 and PF-00299804 ; or PF299804, is an orally bioavailable, highly selective, second-g...

摘要吡昔替尼 PexidartinibPexidartinib, also know as PLX-3397, is a CSF1R inhibitor with IC50 of 20 nM in development by Plexxikon for the trea...

摘要瑞博西尼 RibociclibRibociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cy...

摘要帕布昔利布 PalbociclibPalbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential ...

摘要?，斘髂?AbemaciclibAlso known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1)...

摘要贊魯替尼 ZanubrutinibZanubrutinib, aslo known as BGB-3111, is a potent and highly selective small molecule BTK inhibitor for the potential...

摘要依魯替尼 IbrutinibIbrutinib, also known as PCI-32765, is a potent and orally active BTK inhibitor. Ibrutinib binds to and inhibits BTK act...

摘要阿卡替尼 AcalabrutinibAcalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potent...

摘要康奈非尼 EncorafenibEncorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity...

摘要達帕菲尼 DabrafenibDabrafenib, also known as GSK2118436 , is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antin...

摘要維羅非尼 VemurafenibAlso known as PLX4032, RG7204 or RO5185426, is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BR...

摘要普納替尼 PonatinibPonatinib is an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic...

摘要尼羅替尼 NilotinibNilotinib, also known as AMN107, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-re...

摘要 DasatinibDasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family.

摘要伯舒替尼 BosutinibBosutinib, also known as SKI-606, is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl an...

摘要維奈妥拉 VenetoclaxVenetoclax, also known as ABT-199 or GDC0199, is an orally bioavailable, selective small molecule inhibitor of the anti...

摘要勞拉替尼 LorlatinibLorlatinib, also known as PF-06463922, is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinas...

摘要塞瑞替尼 CeritinibCeritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung canc...

摘要 布格替尼 BrigatinibBrigatinib, also known as AP-26113, is an orally active, potent and selective Dual ALK/EGFR inhibitor.

摘要艾樂替尼 AlectinibAlectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor wi...

摘要瑞格非尼 RegorafenibRegorafenib, also known as BAY 73-4506 ; is an orally bioavailable small molecule with potential antiangiogenic and an...

摘要 舒尼替尼 SunitinibSunitinib free base is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor.

摘要Imatinib is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosin...