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釕紅號：11103-72-3   
英文名稱：Ruthenium Red；C.I. 77800；Ruthenium oxychloride ammoniated   
其他名稱：氧化釕；氧釕(III)   
號：11103-72-3   
Ru3O2Cl6.14(NH3)=786.35    
級別：BR   
純度：～95%   
性狀(以下信息僅供參考)：棕紅色粉末。溶于水、氨,也溶于化鉀溶液及明礬溶液,不溶于乙醇、甘油和丁香油。Z大吸收波長 534(376)nm   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)膠質(zhì)、樹膠、動物組織和細(xì)菌染色   
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amatergic synaptic transmission and dendritic morphology (3). Synergistic interactions between spinophilin and human tumor supressor ARF suggest a role for neurabin-II in cell growth (5).
Function : Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth
Subunit : Interacts with DCLK2 (By similarity). Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C-terminus) with SPATA13 (via C-terminal tail).
Subcellular Location : Cytoplasm > cytoskeleton. Nucleus. Cell projection > dendritic spine. Cell junction > synapse. Cell junction > adherens junction. Cytoplasm. Cell membrane. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > ruffle membrane. Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the post-synaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Post-translational modifications : Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 phosphorylation. Dephosphorylation of Ser-94 is mediated mainly by PP1 and to a lesser extent by PP2A. Phosphorylation of spinophilin disrupts its association with F-actin, but does not affect its binding to PP1.
Similarity : Contains 1 PDZ (DHR) domain.
Database links : UniProtKB/Swiss-Prot: Q96SB3.2
英文名稱  Anti-SLC34A2
中文名稱  磷酸鈉協(xié)同轉(zhuǎn)運(yùn)蛋白抗體
釕紅號：11103-72-3別    名  NaPi-2b; Sodium-dependent phosphate transport protein 2B; Sodium/phosphatecotransporter 2B; Na(+)/Pi cotransporter 2B; Sodium-phosphatetransport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Solute carrier family 34 member 2; NPT2B_MOUSE.
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Mouse, Rat
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 
蛋白分子量  predicted molecular weight: 77kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from mouse SLC34A2 (265-350aa)
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Na+/Pi-cotransporterThis is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows reabsorption of filtered Pi in the proximal tubule.
Function : May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
Subcellular Location : Membrane; Multi-pass membrane protein.
Tissue Specificity : Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum.
Similarity : Belongs to the SLC34A transporter family.
Database links : UniProtKB/Swiss-Prot: Q9DBP0.1
SLC34A2/NaPi-2b是磷酸鈉協(xié)同轉(zhuǎn)運(yùn)蛋白的基因，表達(dá)在動物多種組織中，以肺組織表達(dá)Z高。該基因主要參與無機(jī)磷代謝，與肺泡微石癥、微石癥等多種代謝性疾病發(fā)病相關(guān)。
英文名稱  Anti-Slc4a7/Nbcn1
中文名稱  *協(xié)同轉(zhuǎn)運(yùn)蛋白4-A7抗體
別    名  NBC3; NBCn1; Slc4a7; Nbc; Nbc2; Nbc3; Bicarbonate transporter; BT; NBC2; NBC3; S4A7; SBC2; SLC4A6; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Sodium bicarbonate cotransporter 3; Solute carrier family 4 member 7; Solute carrier family 4 sodium bicarbonate cotransporter member 7; solute carrier family 4, sodium bicarbonate cotransporter, member 7.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat
產(chǎn)品類型  一抗   
研究領(lǐng)域  信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 新陳代謝 
蛋白分子量  predicted molecular weight: 140kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from rat Slc4a7 C-terminus
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.